Project Details
Description
Dr. Tetreault’s team has generated a new mouse model that leads to the
development of eosinophilic esophagitis (EoE) and that show all the features
observed in patients with the disease. This observation is a game changer in
the field of EoE since most mouse models of EoE have failed to recapitulate
all of the features of the human disease and have limited their use or the
implication of the findings obtained from those studies. By performing single
cell RNA sequencing, Dr. Tetreault and her team will determine how changes
in the expression of specific molecules in epithelial cells control the
development of eosinophilic esophagitis. We plan on performing these studies
in mice that have the disease, but also at an earlier time point just before mice
show any obvious features of the disease. We believe that the latter condition
will help us identify the initiating molecular events that are leading to the
development of EoE. This is a crucial question that is still unanswered in the
field of EoE.
Status | Finished |
---|---|
Effective start/end date | 7/1/19 → 6/30/20 |
Funding
- Northwestern Memorial Hospital (Agmt 5/3/2019 // Agmt 5/3/2019)
- Digestive Health Foundation (Agmt 5/3/2019 // Agmt 5/3/2019)
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.