Molecular Pathways of Pain Generation in Osteoarthritis

This project is to investigate how TrkA and TLR signaling contribute to OA progression (both joint damage and pain). We aim to systematically address the role and the interaction of these pathways in joint damage, neuroplasticity, and pain. Dr. Richard J Miller is a professor in the department of Molecular Pharmacology and Biological Chemistry at the Northwestern University Medical School. As co-I, Dr. Richard Miller will carry out work as follows. 1) Assist with in vivo Ca imaging studies on the DRG of mice using OA models prepared by Dr. Anne-Marie’s laboratory at Rush Univ. 2) Assist with in situ hybridization studies using RNAscope. 3) Assist with RNAseq studies on DRG cells.