MPD Research Consortium

  • Crispino, John D (PD/PI)

Project: Research project

Project Details

Description

Co-PI Project 2: John Crispino

Statement of Work

The Northwestern contribution to this grant, led by Dr. John Crispino, is to study the contributions of the reduced expression of GATA1 to primary myelofibrosis. Specifically, his lab will: 1) Compare the differentiation and gene expression of megakaryocytes at the pre-fibrotic and the fibrotic phases of primary myelofibrosis, and 2) Identify alterations in cytokine secretion by PMF megakaryocytes and assay the degree to which they induce fibrosis.
StatusActive
Effective start/end date3/1/182/28/23

Funding

  • Icahn School of Medicine at Mount Sinai (0254-4053-4609//5P01CA108671-12)
  • National Cancer Institute (0254-4053-4609//5P01CA108671-12)

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