Co-PI Project 2: John Crispino Statement of Work The Northwestern contribution to this grant, led by Dr. John Crispino, is to study the contributions of the reduced expression of GATA1 to primary myelofibrosis. Specifically, his lab will: 1) Compare the differentiation and gene expression of megakaryocytes at the pre-fibrotic and the fibrotic phases of primary myelofibrosis, and 2) Identify alterations in cytokine secretion by PMF megakaryocytes and assay the degree to which they induce fibrosis.
|Effective start/end date||3/1/18 → 2/28/23|
- Icahn School of Medicine at Mount Sinai (0254-4053-4609//5P01CA108671-12)
- National Cancer Institute (0254-4053-4609//5P01CA108671-12)
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.