Multicenter AIDS Cohort Study - Part B (Baltimore Center)

In 2007-2009 the Multicenter AIDS Cohort Study (MACS) conducted an evaluation of directly measured glomerular filtration (GFR) using iohexol. In Chicago 175 HIV infected and uninfected men participated in this study. Results of the MACS wide investigation demonstrated that compared to estimated GFR (eGFR) based on serum crestinine , iohexol GFR (iGFR) measurement provided higher GFR values, lower percentages of men with GFR <91, and identification of additional factors associated with reduced GFR (history of AIDS, HCV infection, race). While HIV serostatus did not affect iGFR, relatively more HIV+ men had iGFR<91, regardless of age. ART type, including tenofovir use, was not associated with GFR<91, though this finding may be subject to selection bias and requires confirmation in a longitudinal study. The MACS is now proposing to restudy these men to determine if HIV infection produces greater decreases in GFR than that which occurs with aging. Eighty men are to be studied in 2012-2013 and a second group of 80 in 2013-2014.