Multimodality Quantification of Mitral Valvular Regurgitation in Complex Anatomies Including Percutaneous Mitral Valve Clip Placement

Project: Research project

Project Details

Description

Mitral valvular regurgitation (MVR) is a leading cause of disability in the U.S, affecting over 10% of the elderly population (>75 years). A percutaneous mitral valve (MV) repair using MitraClip has demonstrated to be useful for patients at high risk for standard surgery. However, complex intra-cardiac flow resulting from complex MV anatomy compromises MVR assessment accuracy, critical for patient risk management, and evaluating treatment success. This research proposal aims to improve the quantification accuracy of pre- and post-MitraClip MVR by combining clinical standard Doppler echocardiography and four-dimensional flow magnetic resonance imaging technique to elucidate flow dynamics associated with complex valvular anatomies by exploiting complementary advantage of both techniques. We will use our echo-MRI-compatible MVR flow simulation apparatus to thoroughly investigate the effects of valve geometry and technical settings on MVR quantification accuracy. Based on in-vitro findings, we will develop a modification scheme for conventional quantification methods to achieve better accuracy. We will recruit twenty MVR patients before and after MitraClip intervention to test and refine the developed methods' clinical feasibility. This research will provide better quantification methods and valuable clinical data for the future retrospective exploration of advanced MVR hemodynamic characterization.
StatusActive
Effective start/end date4/1/2112/31/21

Funding

  • Northwestern Memorial Hospital (AGMT 6/11/2021)

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