Multiplatform Variant Prediction (MVP) in Epilepsy

    Project: Research project

    Project Details

    Description

    The goal of this Center without walls is to improve our understanding of the consequences of variants in non-ion channel genes on protein function in patients with epilepsy. These studies will provide a platform for experimental and computational classification of variants of uncertain significance (VUS) that are currently a significant complication in clinical genetic testing. Moreover, we will investigate pathogenic mechanisms implicated in epilepsy beyond the ion-channels; these steps are crucial in the pursuit of novel therapeutic development and the promise of personalized medicine.
    StatusActive
    Effective start/end date9/15/207/31/25

    Funding

    • University of Michigan (SUBK00011889//1 U54 NS117170-01)
    • National Institute of Neurological Disorders and Stroke (SUBK00011889//1 U54 NS117170-01)

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