The goal of this Center without walls is to improve our understanding of the consequences of variants in non-ion channel genes on protein function in patients with epilepsy. These studies will provide a platform for experimental and computational classification of variants of uncertain significance (VUS) that are currently a significant complication in clinical genetic testing. Moreover, we will investigate pathogenic mechanisms implicated in epilepsy beyond the ion-channels; these steps are crucial in the pursuit of novel therapeutic development and the promise of personalized medicine.
|Effective start/end date||9/15/20 → 7/31/25|
- University of Michigan (SUBK00011889//1 U54 NS117170-01)
- National Institute of Neurological Disorders and Stroke (SUBK00011889//1 U54 NS117170-01)