Novel Therapies for Epilepsy Using Biodegradable Immune-Modifying Nanoparticles

Project: Research project

Project Details

Description

The proposed studies are designed to determine the role of blood-derived inflammatory monocytes/macrophages in mediating CNS damage in a two-hit model of status epilepticus (SE) and the mechanism(s) by which early therapy with biodegradable carboxylated monocyte-targeting PLG nanoparticles (IMPs) and regulatory T cells can be employed to limit neuropathology in SE. This work should provide critical pre-clinical information relevant to the translation and clinical testing of the IMP platform for the treatment of SE.
StatusFinished
Effective start/end date8/15/157/31/18

Funding

  • National Institute of Neurological Disorders and Stroke (1R21NS094999-01)

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