Operation RESTORE (Rehabilitative Evaluation, Surgery and Transplant Options for Restoration): Immune assessment of a rodent model of extremity transplantation

Project: Research project

Description

Objective
The goal of our Operation RESTORE allocation is to characterize novel rodent models in extremity transplantation. Given current interest in human extremity transplantation, the level of expertise in the Microsurgical Core within the Northwestern Comprehensive Transplant Center (CTC) allows us to develop these labor intensive procedures. Subsequently, we will ascertain the immunological mechanisms operating in such an experimental model. A subsequent goal is to expand our liver and kidney engineering strategies, already supported through RESTORE, to investigate stem cell applications using federally approved human and rodent embryonic stem cell lines and induced pluripotent stem cells to generate engineered organs and tissues.
StatusActive
Effective start/end date6/1/155/31/20

Funding

  • Northwestern Memorial Hospital (Agr. 07/01/2014 Amnd 3)

Fingerprint

Rodentia
Extremities
Transplantation
Transplants
Induced Pluripotent Stem Cells
Theoretical Models
Stem Cells
Kidney
Cell Line
Liver
Human Embryonic Stem Cells