Optogenetic Control of Tumor Initiation and Tumor Progression in vivo

To develop a system for local light-mediated regulation of proteins in a mouse model. The regulation will be controlled by implantable wireless LED light devices developed by Dr. Rogers’ laboratory. In Years 1 and 2 of this proposal, the Rogers lab at the Northwestern University will provide their recently developed implantable optogenetic devices and help in implementation of these devices in our in vivo experiments. They will also adjust the devices and/or develop new designs if needed for successful completion of the proposed project. Dr. Rogers lab will also provide a novel adhesive material that will enable attachment of the implantable light to the internal organs in the mouse and assist with its initial implementation.