PC-117: Pharmacological Characterization of Seizure Thresholds in a mouse model of Dravet syndrome

Project: Research project

Description

Mice with heterozygous deletion of Scn1a are a model of Dravet syndrome, an infant-onset epileptic encephalopathy most often caused by mutation of SCN1A. Scn1a+/- mice recapitulate many of the features of Dravet syndrome, including spontaneous seizures and premature lethality (Miller et al., 2014; Ogiwara et al., 2007; Yu et al., 2006). The protocol outlined below will determine in a mouse model of disease whether acute administration of OV101/Gaboxadol alters seizure threshold, activity in an open field, or anxiety-like behavior.
StatusActive
Effective start/end date9/14/179/14/20

Funding

  • Ovid Therapeutics Inc. (Prot #IS00006406)

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Myoclonic Epilepsy
Seizures
Pharmacology
Brain Diseases
Acute Disease
Anxiety
Mutation