Cirrhosis, the irreversible damage to the liver, is a leading cause of mortality in the United States (US). It is estimated to affect over half a million patients and result in over 40,000 deaths each year1,2. A recent analysis of Census Bureau Data suggests a steep rise in the age-adjusted death rate due to cirrhosis in the last decade3. Liver cirrhosis is also associated with substantial complications (e.g. ascites, hepatic encephalopathy, GI bleeding) that result in frequent hospitalizations, disability, and mortality 4–9. As with many diseases, prevalence and incidence are collected via National Health and Nutrition Examination Survey (NHANES), a population based self-report of disease conditions. Unfortunately, many patients afflicted with liver disease are missed by patient self-report, with one study finding that 69% of patients with liver disease were unaware of this fact 2. Hence, one of the greatest challenges related to liver cirrhosis is that no accurate estimate of the true incidence and prevalence of liver cirrhosis in the US exists. The PCORnet Surveillance Program grant is an ideal setting to tackle this important epidemiologic problem because clinical data are so essential in early identification of this disease before complications occur.
|Effective start/end date||4/1/19 → 8/31/20|
- Harvard Pilgrim Health Care, Inc. (Agmt. 8/6/2019)
- Patient-Centered Outcomes Research Institute (Agmt. 8/6/2019)
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