To assess the efficacy and safety of early neuromuscular blockade in reducing mortality and morbidity in patients with moderate-severe ARDS in comparison to a control group with no routine early neuromuscular blockade. Hypothesis: Early neuromuscular blockade will improve mortality prior to discharge home before day 90, in patients with moderate-severe ARDS. Study Design: Multi-center, prospective, 2-arm, unblinded, randomized clinical trial of two management strategies of neuromuscular blockade (also called skeletal muscle relaxant and muscle relaxant).
|Effective start/end date||8/1/17 → 4/30/21|
- Cleveland Clinic Lerner College of Medicine of CWRU (868-SUB//U01HL123009-05)
- National Heart, Lung, and Blood Institute (868-SUB//U01HL123009-05)
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