Pharmacological Inhibitors of Nedd4 ubiquitin ligase as anticancer therapeutics

  • Statsyuk, Alexander Vladimirovich (PD/PI)

Project: Research project

Project Details


IGF-1 and Insulin cell growth pathways activate downstream PI3K/Akt cell signaling and are one of the most frequently activated cell growth pathways in human cancers. Nedd4-1 is a critical HECT E3 ubiquitin ligase, which is required for IGF-1/Insulin cell signaling, therefore the inhibition of Nedd4-1 with small molecule inhibitors is a promising strategy to treat human cancers. The proposed project addresses this need by discovering first-in-class covalent inhibitors of Nedd4-1 enzyme, which inhibit its processivity.
Effective start/end date7/1/158/31/16


  • National Institute of General Medical Sciences (5R01GM115632-02)


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