Phase II trial of mTORC1/mTORC2 inhibitor AZD2014 for sporadic meningioma

Project: Research project

Project Details

Description

In this study, patients with recurrent or progressive grade 2 and 3 meningiomas will be enrolled for treatment with the dual mTORC1/mTORC2 inhibitor, AZD2014. We plan to recruit a total of 15 patients in years 2, 3 and 4.

We have an extremely busy neuro-oncology program at Northwestern Memorial Hospital with multiple active clinical trials. Currently, we do not have any ongoing trials for recurrent meningioma, and this trial would be of great interest for our patients with recurrent meningiomas for which they are little treatment options. We will gladly enroll eligible patients to this study, should it be funded.
StatusActive
Effective start/end date8/10/167/31/21

Funding

  • Massachusetts General Hospital (Mod. 05//5R01CA201130-04)
  • National Cancer Institute (Mod. 05//5R01CA201130-04)

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