Platform for Long-Term Delivery of Anti-Angiogenic Peptides for Intravitreal Treatment of Neovascular Eye Disease

Project: Research project

Project Details

Description

We will design a biodegradable drug delivery platform for long acting anti-angiogenic therapy in neovascular AMD. The experiments planned will establish anti-angiogenic potency of the modified peptides (Henkin lab) using in vitro assays (Volpert lab) followed by in vivo validation in laser-induced CNV mouse model (Fawzi lab). The most potent peptide will then be linked into a biodegradable polymer (Shea lab). The bioactivity and safety of this polymer will finally be validated in vivo using a subretinal matrigel rat model of prolonged CNV formation (Fawzi lab).
StatusFinished
Effective start/end date4/1/139/30/15

Funding

  • Macula Society (Ltr. 4/10/13)

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