Pre-transplant autoimmunity and lung allograft dysfunction

Project: Research project

Project Details

Description

The objective of this proposal is to identify non-HLA lung tissue specific antigens that would be the target of pre-existing antibodies in the recipients.

Hypothesis 1) The end-stage lung disease in patients awaiting lung transplantation leads to an inflammatory milieu predisposing to the development of autoimmunity against lung-specific antigens; 2) Pre-existing autoantibodies in lung transplant recipients can bind to the lung-specific antigens in donor lungs following transplantation and lead to PGD; 3) Pre-existing autoantibodies are not detected by the contemporary methods used for cross-matching and HLA antibody testing.
StatusFinished
Effective start/end date7/1/146/30/16

Funding

  • Gift of Hope Organ & Tissue Donor Network (Agr. 8/18/2014)

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