Preclinical testing of RNAi therapeutics in glioma models

Project: Research project

Project Details


Assess the effectiveness of Alnylam’s neuronal targeted siRNA conjugates as therapeutic agents in in vivo glioma models. Experiments will evaluate efficiency of delivery and target gene knockdown in clinically relevant animal models of glioma. We will test multiple siRNA targets, which may include: CDK1, HIF1α, STAT3, Nucleolin, FGL2, and AKT1/2. Together, this information will provide the basis for defining additional target selection and therapeutic approaches for RNAi therapeutics in glioma.
Effective start/end date9/1/228/31/23


  • Alnylam Pharmaceuticals, Inc. (Signed 9/20/22)


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