Prediction of Outcomes in Preterm Infants with Severe Bronchopulmonary Dysplasia (sBPD)

The proposed project will be conducted over a 1-year period. Our central hypothesis is that specific, modifiable risk factors can be isolated, and we will test the independent association between PGF and the short-term outcomes associated with sBPD. Specific Goals and Objectives To determine the clinical risk factors predicting short-term outcomes in infants with established sBPD and born <32 weeks' gestation, through the following specific aims: Aim #1: To identify maternal and infant covariates associated with the development of short-term outcomes (survival without gastrostomy or trachoestomy tube insertion) in infants with sBPD, and Aim #2: To test the hypothesis that postnatal growth failure (PGF) is an independent predictor of neonatal outcomes associated in infants with sBPD.