Prevalence and Determinants of Illness-Related Post Traumatic Stress (PTS) in Inflammatory Bowel Disease Patients

  • Taft, Tiffany Noel (PD/PI)
  • Quinton, Sarah (Co-Investigator)

Project: Research project

Project Details


Post-traumatic stress (PTS), or the psycho-physiological response to a traumatic or life threatening event, has the potential to degrade patient lives1. Emerging evidence suggests a complex relationship between PTS, the brain-gut axis, gut microbiome, and immune function2, 3. In the first study of IBD-related PTS in the United States, we found approximately one-third of inflammatory bowel disease (IBD) patients report significant PTS symptoms, and the reasons appear multi-faceted. We hypothesize PTS prevalence rates in a larger cohort of IBD patients will be similar to the preliminary study (~30%). We expect patients to report experiences related to hospitalization and surgery as main reasons for PTS symptoms. Aim 1: IBD Partners registrants will complete a supplemental online questionnaire. Aim 2: Data previously collected in the IBD Partners database (age, gender, race, ethnicity, IBD diagnosis, medications, surgical and hospital history, health-related quality of life score) will be obtained and merged with Aim 1 data. Aim 3: 20 patients endorsing at least 1 traumatic event related to their IBD experiences will complete the interview, based on standard sample sizes for qualitative studies to ensure enough information is collected17. An additional 20 patientswho do not endorse traumatic experiences related to IBD will complete the same interview for comparison. Interviews will be audio recorded and transcribed, with permission. Qualitative analysis done using NVivo software will identify relevant PTS themes, with consensus from study team members. In addition to the interview, participants will complete the following PTSD Diagnostic Scale for DSM5 and Demographic and Disease Information.
Effective start/end date7/1/196/30/21


  • Northwestern Memorial Hospital (B.7 NMH 17 // B.7 NMH 17)
  • Digestive Health Foundation (B.7 NMH 17 // B.7 NMH 17)


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