Profiling changes in enzyme activities arising from viral infection using SAMDI mass spectrometry

Project: Research project

Project Details


This sub-project is a collaboration with members of the Wake Forest Institute for Regenerative Medicine on the DTRA “Pathogenesis and Toxicity Forecasting Using Multi-Organoid Systems (PATMOS)” program. The goal of this subproject is to provide insight into the effects of viral infection on key enzyme activities of infected cells. We will measure changes in enzyme activities of cells from organoid systems infected with viruses, using Self-Assembled Monolayers for Matrix-Assisted Laser Desorption/Ionization (SAMDI) mass spectrometry. This information has potential to elucidate important biological ramifications of infection and identify strategic targets for intervention to reduce or eliminate detrimental indications arising from infection. The enzymatic activity data produced from this investigation will also provide a valuable, complementary data set to the genomic, transcriptomic and proteomic data produced from other PATMOS research to empower a more comprehensive machine-learning analysis of biological responses.
Effective start/end date10/1/229/30/23


  • Wake Forest University Health Sciences (1667-45829-11000000777 // W15QKN-16-9-1002)
  • Picatinny Center for Contracting and Commerce (1667-45829-11000000777 // W15QKN-16-9-1002)


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