Progesterone Signaling and Blockade in Human Breast Tumorigenesis and Prevention

Project: Research project

Description

Exposure to progesterone and progestins has been implicated in the promotion of breast cancer. Blockade of progesterone/progestin signaling is therefore an attractive candidate strategy for breast cancer prevention, and possibly for therapy of early breast cancer. We propose to test selective progesterone receptor modulators for this purpose through a series of laboratory experiments in cell lines and animals, and finally in human breast tissue.
StatusActive
Effective start/end date8/3/157/31/20

Funding

  • National Cancer Institute (5R01CA192124-05)

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Progesterone
Carcinogenesis
Breast
Progestins
Breast Neoplasms
Progesterone Receptors
Cell Line
Therapeutics