Exposure to progesterone and progestins has been implicated in the promotion of breast cancer. Blockade of progesterone/progestin signaling is therefore an attractive candidate strategy for breast cancer prevention, and possibly for therapy of early breast cancer. We propose to test selective progesterone receptor modulators for this purpose through a series of laboratory experiments in cell lines and animals, and finally in human breast tissue.
|Effective start/end date||8/3/15 → 7/31/20|
- National Cancer Institute (5R01CA192124-05)