Prospective trial evaluating the long-term outcomes associated with the use of MTF allograft cartilage in cosmetic and reconstructive rhinoplasty procedures

Project: Research project

Project Details


Autogenous cartilage is the most common source of graft material for nasal reconstruction and rhinoplasty. Autogenous cartilage is typically harvested from the septum, concha, and rib, and is widely utilized for structural support as well as for cosmetic contour. Most primary rhinoplasty procedures utilize septal and conchal cartilage, and most reconstructive procedures that require cartilage will utilize conchal cartilage. However, there are situations wherein septal or conchal cartilage is inadequate (secondary rhinoplasties, many ethnic rhinoplasties, procedures in older patients where cartilage can become mineralized and brittle, as well as complex reconstructive procedures) or unavailable. Common complications of autogenous grafts in rhinoplasties include resorption (0.5% to 5%3,4,5,8), infection (1.5% to 9%2,7,8), and warping (1 to 25.8%1,6,7,8,9). In addition, use of autogenous cartilage for nasal reconstruction has other significant drawbacks such as donor site morbidity (e.g. pneumothorax, septal perforations, bleeding) and long operating times required to harvest the graft. For this reason, allogeneic grafts have been proposed and utilized as an alternative graft source in rhinoplasty procedures. While cadaveric cartilage conceptually provides a good alternative to autogenous cartilage, problems with tissue integrity can arise due to the harsh processing procedures often used to achieve the sterility necessary for safe implantation. Common approaches to sterilizing allogenous cartilage include heat, hydrogen peroxide, and terminal sterility (ethylene oxide and gamma irradiation), all of which are convenient and effective at achieving sterilization; however, their effect on the structure and/or chemistry of the cadaveric cartilage may be detrimental, leading to decreased strength and efficacy following implantation. Recently, a novel “off-the-shelf” FDA-approved pre-shaped costal cartilage allograft has became commercially available through the Mus
Effective start/end date10/20/1610/31/21


  • Musculoskeletal Transplant Foundation, Inc. (Agreement 10/15/16)


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