Proteome Biology of Noise Induced Hearing Loss

Project: Research project

Description

250 million people worldwide have moderate to severe hearing loss, which significantly reduces the quality of life due to the central role of verbal communication. On an economic scale, the total negative impact of hearing loss is greater than that of multiple sclerosis, spinal cord injury, stroke, epilepsy, Parkinson’s and Huntington’s disease. The most common causative factor among the defined hearing loss etiologies is excessive noise (noise induced hearing loss or NIHL). We hope that our research findings will aid in the reduction of noise-induced hearing loss by identifying new protein pathways responsible for NIHL. Our current quantitative proteomic data shows that excess noise causes substantial proteome perturbations in the cochlea and include up regulation of discrete classes of proteins such as kinases and proteasome subunits. We are actively working to verify the noise sensitive proteins with shorter noise exposures, antibodies, and aim to determine which cells express the perturbed proteins with in situ hybridization.
StatusFinished
Effective start/end date2/1/151/31/18

Funding

  • National Institute on Deafness and Other Communication Disorders (5R00DC013805-04)

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Noise-Induced Hearing Loss
Proteome
Noise
Hearing Loss
Proteins
Cochlea
Huntington Disease
Proteasome Endopeptidase Complex
Spinal Cord Injuries
Proteomics
Multiple Sclerosis
In Situ Hybridization
Parkinson Disease
Epilepsy
Phosphotransferases
Up-Regulation
Stroke
Communication
Economics
Quality of Life