250 million people worldwide have moderate to severe hearing loss, which significantly reduces the quality of life due to the central role of verbal communication. On an economic scale, the total negative impact of hearing loss is greater than that of multiple sclerosis, spinal cord injury, stroke, epilepsy, Parkinson’s and Huntington’s disease. The most common causative factor among the defined hearing loss etiologies is excessive noise (noise induced hearing loss or NIHL). We hope that our research findings will aid in the reduction of noise-induced hearing loss by identifying new protein pathways responsible for NIHL. Our current quantitative proteomic data shows that excess noise causes substantial proteome perturbations in the cochlea and include up regulation of discrete classes of proteins such as kinases and proteasome subunits. We are actively working to verify the noise sensitive proteins with shorter noise exposures, antibodies, and aim to determine which cells express the perturbed proteins with in situ hybridization.
|Effective start/end date||2/1/15 → 1/31/18|
- National Institute on Deafness and Other Communication Disorders (5R00DC013805-04)
Noise-Induced Hearing Loss
Proteasome Endopeptidase Complex
Spinal Cord Injuries
In Situ Hybridization
Quality of Life