Prox1 in Mammalian Lymphangiogenesis

Project: Research project

Project Details

Description

Under normal conditions, the lymphatic network maintains fluid homeostasis by draining lymph fluid from
extracellular spaces, absorbs lipids from the intestinal tract, and transports white blood cells and antigenpresenting
cells to lymphoid organs. During infection, the lymphatic vasculature is the main route for the
immune response, and in cancer, tumor cells migrate via the lymphatic vasculature to lymph nodes and distant
organs. Malfunctions of the lymphatic system can lead to congenital or inherited disorders such as
lymphedema, a disfiguring and disabling disorder that is caused by imbalance in lymph absorption and often
characterized by swelling of the extremities. A better knowledge of the cellular and molecular features
controlling normal lymphatic vasculature development should facilitate our understanding of pathologic
lymphatic conditions that lead to inflammation, autoimmunity, cancer, and obesity and to improve the clinical
treatment of primary and secondary forms of lymphedema.
StatusFinished
Effective start/end date9/1/156/30/17

Funding

  • National Heart, Lung, and Blood Institute (5R01HL073402-15)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.