Radiation induced cancer risk reduction as a function of dose protraction: interspecies comparison

Project: Research project

Project Details

Description

Ionizing radiation (IR) causes damage to living organisms. The health effects of IR for different total doses and dose rates at which IR was delivered have to be defined by statistical analyses based on whole organism endpoints such as an increase in the risk for development of cancer or an increased risk of life shortening. The factor by which a total dose could be increased, if protracted, for the same final biological effect, is known as dose and dose-rate effectiveness factor (DDREF). DDREF is factor used for regulation of occupational and public radiation exposure limits for protracted exposures. By using an extensive animal dataset that enables direct comparison of protracted and acute radiation exposures, we found that the current DDREF estimate is inappropriate (Haley et al. 2015), but that a dose-rate effectiveness factor (DREF) evaluation is feasible. We propose to refine DREF values for life-shortening and cancers; this work is of interest to the International Commission on Radiological Protection (ICRP) (letter attached) and other regulatory agencies
StatusActive
Effective start/end date8/16/177/31/22

Funding

  • National Cancer Institute (5R01CA221150-03)

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