Rapid diagnostic testing to guide antibiotic therapy in drug resistant pneumonia

Project: Research project

Project Details

Description

We have designed two related specific aims to address the major goal of this proposal: to show that an antibiotic strategy based on rapid automated PCR will significantly reduce antibiotic exposure and new antibiotic resistant infections in ICU patients with suspected MRSA pneumonia.

Aim 1. Determine the operating characteristics and time to diagnosis of the PCR based system compared to DRP risk factors and bacterial cultures for the diagnosis of MRSA pneumonia. Hypothesis 1a: PCR will exhibit a faster time to diagnosis, and have a higher sensitivity and potentially a lower specificity compared to traditional cultures. Hypothesis 1b: automated PCR will identify patients without MRSA even among patients who are at high risk for DRPs.

Aim 2. Conduct a prospective, randomized clinical trial in which automated PCR is used to guide antibiotic therapy in critically ill adults with risk factors for multidrug resistant pneumonia. We will conduct a pilot single center randomized clinical trial of critically ill subjects with suspected pneumonia to compare an antibiotic strategy based on PCR to an antibiotic strategy based
on DRP risk factors and bacterial cultures. Hypothesis: when automated PCR is used to guide antibiotic therapy, antibiotic exposure will be reduced in critically ill subjects with pneumonia.
StatusFinished
Effective start/end date1/1/1612/31/17

Funding

  • Northwestern Memorial Hospital (Grant Agmt #7 Signed 2/3/16, Amd #1)

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.