Advancing Multiparametric Kidney Functional Magnetic Resonance Imaging to Identify Kidney Histopathologic Lesions

  • Srivastava, Anand (PD/PI)

Project: Research project

Project Details

Description

Patients with chronic kidney disease (CKD) are at increased risks of developing cardiovascular disease, progressing to end stage renal disease, and dying prematurely. New therapies are critically needed to improve outcomes. Through interrogation of kidney biopsy specimens of patients undergoing a research kidney biopsy, The Kidney Precision Medicine Project (KPMP) aims to identify novel pathways and therapeutic targets in patients with CKD. Novel non-invasive tools to phenotype and complement the rich clinical, histopathologic, and molecular data are required. Prior studies implicate decreased kidney perfusion and resultant chronic hypoxia in the pathogenesis of kidney fibrosis. Advancement of novel imaging biomarkers of important physiologic and histopathologic data of the kidney may provide a non-invasive tool to phenotype patients with CKD. Although imaging is underdeveloped in CKD, gadolinium-free multiparametric kidney functional magnetic resonance imaging (fMRI) provides non-invasive assessments of kidney oxygenation, fibrosis, and perfusion that may enhance clinical phenotyping of KPMP participants. Our exciting preliminary data suggest that multiparametric kidney fMRI can be incorporated into multicenter studies with low inter-site variability, and the kidney fMRI-derived measurements have low intra-reader, inter-reader, and intra-participant variability. In addition, the kidney fMRI-derived assessments of hypoxia, fibrosis, and malperfusion are able to differentiate patients with CKD from healthy volunteers and may have prognostic value. In the proposed studies, we will incorporate multiparametric kidney fMRI as a non-invasive tool to phenotype KPMP participants undergoing a research kidney biopsy for CKD. In year 1, we will perform multiparametric kidney fMRI in 15 participants at Boston University Medical Center (BUMC) and demonstrate low intra-reader, inter-reader, and intra-participant variability among kidney fMRI measurements. After the development an
StatusFinished
Effective start/end date7/1/206/30/22

Funding

  • Boston Medical Center (01_NWU_05439 // 5U2CDK114886-4)
  • National Institute of Diabetes and Digestive and Kidney Diseases (01_NWU_05439 // 5U2CDK114886-4)

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