Rat Paraspinal Neuroinflammation Model-to Study Host Response to rhPDGF-BB Combined with a Beta-tricalcium Phosphate (b-TCP)/Bovine Collagen Matrix

Project: Research project

Description

PDGF-BB (Platelet Derived Growth Factor-B chain homodimer) is a polypeptide growth factor released from platelets and acts early in the wound healing cascade as a chemoattractant and mitogenic agent, for both osteoprogenitor cells and differentiated osteoblasts [1-3]. PDGF-BB also plays an important role in the formation of new blood vessels[2, 4]. These properties make PDGF-BB’s role vital in the recruitment and amplification of the osteoblast lineage cells and promoting healing at the bone fusion site [5-7].
StatusActive
Effective start/end date5/9/185/9/21

Funding

  • Wright Medical Technology, Inc. (Agmt 05/09/18)

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Collagen
Osteoblasts
Proto-Oncogene Proteins c-sis
Chemotactic Factors
Wound Healing
Blood Vessels
Intercellular Signaling Peptides and Proteins
Blood Platelets
Bone and Bones
Peptides
beta-tricalcium phosphate
platelet-derived growth factor BB