REDD1 dissociates the therapeutic and adverse effects of glucocorticoids in skin

Glucocorticoids remain the most commonly used anti-inflammatory drugs in dermatology, however, their use is limited by the development of side effects, particularly skin atrophy. We discovered that REDD1 is causatively involved in skin atrophy. The proposed studies will test the novel concept of safe anti-inflammatory therapy in which glucocorticoids are combined with REDD1 inhibitors.