Chronic pancreatitis is inflammation of the pancreas that impairs a patient’s ability to digest food and make pancreatic hormones. When medical therapy and standard surgical management fail to provide relief to those patients, total pancreatectomy (TP), that is the removal of the entire pancreas, is the only way to relieve the pain. After TP, the pancreatic islets that are responsible to produce insulin and control blood glucose, will be isolated from the removed pancreas and transplanted back to the same patient by infusion to the liver portal vein. Instead of developing insulin-dependent diabetes following a total pancreatectomy, the patients will still be able to manage blood sugar as prior to the removal of the pancreas. However, the liver is not an ideal location for islet transplantation, because it limits the total number of islets that can be transplanted and presents a hostile oxidative environment for the survival of the transplanted islets. To address this critical problem, we propose to use the omentum, which is the fat tissue surrounding abdominal organs, as the new islet transplantation site; and to use an antioxidant macromolecule, poly (polyethylene glycol citrate-co-N isopropyl acrylamide) or PPCN, to protect the islets from oxidative stress during transplantation.
|Effective start/end date||7/1/19 → 6/30/22|
- U.S. Army Medical Research and Materiel Command (W81XWH1910230)