Resveratrol as a Therapeutic to Reverse the Adverse Effects of Cigarette Smoke on Bone

Project: Research project

Description

Our previous work implicates the Aryl hydrocarbon receptor (Ahr) in mediating
the inhibitory effects of cigarette smoke (CS) on bone regeneration. In the current proposal, we hypothesize that chronic exposure to cigarette smoke extract (CSE) will inhibit osteogenic differentiation and spine fusion in the rat, and treatment with the Ahr antagonist, resveratrol, will reverse such effects. This hypothesis will be addressed with the following.
StatusFinished
Effective start/end date1/1/1710/1/18

Funding

  • Cervical Spine Research Society (AGREEMENT #30216864)

Fingerprint

Aryl Hydrocarbon Receptors
Smoke
Tobacco Products
Bone and Bones
Bone Regeneration
Spine
Therapeutics
resveratrol