Resveratrol as a Therapeutic to Reverse the Adverse Effects of Cigarette Smoke on Bone

Our previous work implicates the Aryl hydrocarbon receptor (Ahr) in mediating the inhibitory effects of cigarette smoke (CS) on bone regeneration. In the current proposal, we hypothesize that chronic exposure to cigarette smoke extract (CSE) will inhibit osteogenic differentiation and spine fusion in the rat, and treatment with the Ahr antagonist, resveratrol, will reverse such effects. This hypothesis will be addressed with the following.