We will examine the effects of Ataxion001 in young adult, male, Sprague Dawley rats undergoing five days of delay eyeblink conditioning and three days of tone alone extinction. There will be 8-10 rats per group (vehicle, 3mg/kg, 20mg/kg) depending upon behavioral variability and statistical differences. Our goal is to determine if Ataxion001, a small molecule positive allosteric modulator of SK2/3 channels, has a significant effect on acquisition or extinction of conditioned blink responses.
|Effective start/end date||12/1/15 → 6/30/16|
- Ataxion, Inc. (Agmt 11/11/15)
Sprague Dawley Rats