ROS and HIF-1α in right ventricular hypertrophy in pulmonary hypertension

Project: Research project

Description

Pulmonary hypertension (high blood pressure in the lungs) is associated with hypoxia (low oxygen levels) in lung cells. Patients with pulmonary hypertension develop thickening of the right heart wall. We have previously shown that inhibition of a HIF-1α, a protein important during hypoxia, in lung blood vessels prevents pulmonary hypertension, but does not block right heart wall thickening. We propose that HIF-1α is directly involved in right heart wall thickening during the development of pulmonary hypertension. This project will investigate the role of HIF-1α in right heart wall thickening in pulmonary hypertension in order to better understand how this disease develops. If true, then emerging drugs to limit HIF activity could prove useful in the treatment of this disease.
StatusFinished
Effective start/end date7/1/166/30/19

Funding

  • Francis Family Foundation (Award Letter 01/29/2016)

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Right Ventricular Hypertrophy
Pulmonary Hypertension
Lung
Heart Block
Blood Vessels
Oxygen
Hypertension
Pharmaceutical Preparations
Proteins