RRF Medical and Graduate Student Preceptorship: Linh (Jason) Ngo Khanh

  • Varga, John (PD/PI)

Project: Research project

Project Details

Description

I will be the lead investigator on a project investigating the effect of dietary choline on fibrosis in systemic sclerosis. This project has 2 aims:

Aim 1: To test the hypothesis that a choline-rich diet, via gut microbial production of TMAO, will increase the severity of skin and lung fibrosis and inflammation in a mouse model of systemic sclerosis.
Aim 2: To test the hypothesis that endothelial-mesenchymal transition (endoMT) is a key fibrotic mechanism linking TMAO to vascular injury and fibrosis.
StatusFinished
Effective start/end date4/1/193/31/20

Funding

  • Rheumatology Research Foundation (AGMT 8/26/19)

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