I will be the lead investigator on a project investigating the effect of dietary choline on fibrosis in systemic sclerosis. This project has 2 aims: Aim 1: To test the hypothesis that a choline-rich diet, via gut microbial production of TMAO, will increase the severity of skin and lung fibrosis and inflammation in a mouse model of systemic sclerosis. Aim 2: To test the hypothesis that endothelial-mesenchymal transition (endoMT) is a key fibrotic mechanism linking TMAO to vascular injury and fibrosis.
|Effective start/end date||4/1/19 → 3/31/20|
- Rheumatology Research Foundation (AGMT 8/26/19)
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