Staging Intracranial Hemodynamic Failure with MRI

Project: Research project

Description

Ischemic stroke is the third leading cause of death and disability in the industrialized world. In the US alone, between 500,000 and 750,000 people are affected by stroke each year. Intracranial atherosclerotic Disease (ICAD), i.e. the gradual accumulation of cholesterol plaque in the wall of an artery, is considered the leading cause of stroke worldwide. The goal of this American Heart Association Grant-in-Aid grant is to develop a diagnostic “stress test” that can be used to identify a ICAD patient's risk of stroke. In an ischemic stroke, blood flow to parts of the brain is reduced below the metabolic needs and neuronal cell death ensues. Early detection and treatment of an intracranial stenosis has the potential to prevent a stroke. Angioplasty and stenting of stenosis may help patients with insufficient perfusion, but the procedure carries a significant risk. Conversely, there is high rate of stroke in many cases where less aggressive medical therapy is prescribed. Stratifying patients for treatment is complicated by the fact that many patients develop adequate collateral circulation to compensate for even severe stenosis and do not need intervention. There is currently no robust way to evaluate the degree to which cerebrovascular disease compromises an individual’s compensatory reserve, and consequently their risk of future stroke. The unmet need that we will address is to develop an imaging-based diagnostic test that quantifies the stage of hemodynamic failure resulting from ICAD. Our research proposal will follow a two year study plan, bases around two specific aims with well-defined metrics of success.
StatusFinished
Effective start/end date7/1/146/30/17

Funding

  • American Heart Association Midwest Affiliate (14GRNT20380798)

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Hemodynamics
Stroke
Pathologic Constriction
Organized Financing
Routine Diagnostic Tests
Cerebrovascular Disorders
Collateral Circulation
Exercise Test
Angioplasty
Cause of Death
Cell Death
Research Design
Therapeutics
Arteries
Perfusion
Cholesterol
Brain