Strengthening circadian signals to enhance cardiometabolic function

The current rapid growth of the aged population and of the prevalence of age-related chronic disorders, such as diabetes and cardiovascular disease, coupled with advances in the scientific knowledge of circadian biology and the evidence of circadian disruption with aging, indicate the transformative potential of circadian based strategies for maximizing healthy aging. In this application, we propose to build on this growing knowledge and our expertise and experience in circadian biology, aging and clinical research to advance our understanding of the interaction between centrally regulated circadian rhythms, sleep and peripheral tissue clocks in cardiometabolic aging and to translate these findings to interventions to enhance circadian rhythmicity, and thus improve sleep and cardiometabolic health of older adults.