Structure function analysis of ERG and GATA1 meg-erythroid development and leukemia

  • Crispino, John D (PD/PI)

Project: Research project

Project Details

Description

Dr. Crispino will perform the experiments to determine the role of the GATA2-ERG axis in growth and differentiation of G1ME and G1E cell line models. These experiments include chromatin immunoprecipitation of GATA factors and histone modifications. In addition, he will overexpress wild-type ERG and the pointed domain mutant in the cell line models and study the effect on differentiation and megakaryocyte versus erythroid specification. Finally, he will also provide expertise and reagents to support Dr. Izraeli’s aims.
StatusFinished
Effective start/end date10/1/149/30/18

Funding

  • United States-Israel Binational Science Foundation (2013412)

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