Subacute Dosing - Effect on spontaneous seizures and survival in Scn1a+/- Dravet Mice

Project: Research project

Project Details

Description

Mice with heterozygous deletion of Scn1a are a model of Dravet syndrome, an infant-onset epileptic encephalopathy most often caused by mutation of SCN1A. Scn1a+/- mice recapitulate many of the features of Dravet syndrome, including spontaneous seizures and premature lethality (Miller et al., 2014; Ogiwara et al., 2007; Yu et al., 2006). In order to determine the effect of PRAX-562 on spontaneous seizures and survival, F1.Scn1a+/- Dravet mice will be treated with PRAX-562compounded in chow or vehicle control chow. Feeding test article compounded in chow minimizes stressful manipulations that may provoke seizures in Scn1a+/- mice and adversely influence outcomes. In our experience, formulation of test article in chow is more reliable and efficient than administration in drinking water.
StatusActive
Effective start/end date10/1/219/30/22

Funding

  • Praxis Precision Medicines, Inc. (Kearney AGMT 10/12/21)

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