Variation in the NOS1AP gene, which encodes a regulatory protein of neuronal nitric oxide synthase, has been associated with electrocardiographic QT interval in several studies. Our investigative team recently described a novel association between the QT interval and reduced tissue Doppler early diastolic relaxation velocity (E’), a marker of abnormal diastolic cardiac mechanics. Prior studies of patients with long QT syndrome (LQTS) have also identified abnormalities in both systolic and diastolic cardiac mechanics in patients with prolonged QT. We now propose to determine whether variation in the NOS1AP gene is associated with abnormal cardiac mechanics, particularly diastolic dysfunction (DD). If an association exists, our findings would provide new insight into the underlying mechanisms of cardiac dysfunction, and pharmacologic targeting of NOS1AP could be a new avenue for improving diastolic function.
|Effective start/end date||7/1/12 → 10/31/12|
- American Heart Association (Award Letter 10/19/12)
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