T cell epigenetics in Alzheimer's disease

This proposal aims to define the genome-wide chromatinaccessibility landscape of CD8 T cells in Alzheimer’s disease. It is hypothesized that antigen-experienced CD8 T cells contribute to disease via effector-driven antigen control that will be reflected by uncovering specific regions of accessible chromatin. Specifically, we expect to uncover pro-inflammatory genes such as cytokines, chemokines and cytotoxic molecules that will implicate CD8 T cells in AD neuroinflammation. These experiments could elucidate the mechanism by which T cells contribute to AD pathogenesis and may reveal novel immunotherapeutic targets for AD.