T cell epigenetics in Alzheimer's disease

Project: Research project

Project Details


This proposal aims to define the genome-wide chromatinaccessibility landscape of CD8 T cells in Alzheimer’s disease. It is hypothesized that antigen-experienced CD8 T cells contribute to disease via effector-driven antigen control that will be reflected by uncovering specific regions of accessible chromatin. Specifically, we expect to uncover pro-inflammatory genes such as cytokines, chemokines and cytotoxic molecules that will implicate CD8 T cells in AD neuroinflammation. These experiments could elucidate the mechanism by which T cells contribute to AD pathogenesis and may reveal novel immunotherapeutic targets for AD.
Effective start/end date2/21/222/20/24


  • Alzheimer's Disease Research Foundation (AGMT 1/27/23)


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