Target validation of thalamic T-type calcium channels in a mouse model of Dravet Syndrome

Project: Research project

Description

A common trait among genetic epilepsies is variable expressivity, or the spectrum of symptom severity
in patients bearing the same genetic mutation, which suggests that clinical severity is influenced by
genetic modifiers. We previously identified a modifier gene, Cacna1g, that influences seizure
susceptibility in multiple mouse models of epilepsy, including a mouse model of Dravet Syndrome.
One goal of this fellowship is target validation of Cacna1g and related gene Cacna1h using genetic
and pharmacological tools in a mouse model of Dravet Syndrome, a critical step in determining if
Cacna1g and Cacna1h may be novel targets for therapeutic intervention. The other goal of this
fellowship is to use activity mapping to determine whether thalamocortical neurons are activated
during seizure initiation or propagation in a mouse model of Dravet Syndrome.
StatusFinished
Effective start/end date1/1/1712/31/17

Funding

  • Dravet Syndrome Foundation, Inc. (Agmt 01/05/17)

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T-Type Calcium Channels
Myoclonic Epilepsy
Epilepsy
Modifier Genes
Seizures
Pharmacology
Neurons
Mutation
Genes