Targeting abnormal alveolar immune activation in COVID-19

Project: Research project

Project Details


A minority of patients infected with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) develop severe pneumonia and the acute respiratory distress syndrome (ARDS), but these severe infections account for all of the public health and societal impacts of the virus. Understanding the pathobiology of severe COVID-19 can only be accomplished by careful studies conducted on human tissues and patients with severe disease. Our group at Northwestern Medicine had been doing advanced NIH-funded research to study pneumonia for years in anticipation of a pandemic like COVID-9. As a result, we have collected and cryopreserved what is likely the world’s largest and most comprehensive set of bronchoalveolar lavage samples and paired serum samples from 100 patients with respiratory failure secondary to SARS-CoV-2 pneumonia and 252 patients with severe pneumonia from other respiratory pathogens collected prior to and during the pandemic. We seek funding to exploit this unique resource with a goal of answering pressing questions that arise from our preliminary analysis. These questions will have immediate impact on clinical care for patients with COVID-19, not only at Northwestern Medicine, but also around the world.
Effective start/end date4/1/213/31/24


  • Northwestern Memorial Hospital (Budinger 6/21/21)


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