Targeting linear ubiquitination to attenuate inflammation and promote repair after IAV infection

Project: Research project

Project Details

Description

Recovery from severe influenza is a clinically important yet understudied process. A central hypothesis of this project is that the persistence of respiratory failure and the development of multiple organ dysfunction in patients with pneumonia/ARDS is a consequence of the failure of normal mechanisms of inflammation resolution and lung tissue repair. We propose to investigate the process of recovery from viral pneumonia with a focus on how the dysregulated production of inflammatory mediators from the lung epithelium prevents epithelial regeneration by inhibiting the reparative function of monocyte-derived alveolar macrophages.
StatusActive
Effective start/end date9/1/208/31/24

Funding

  • National Heart, Lung, and Blood Institute (1R01HL154686-01)

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