Targeting the Achilles' shield of TNBC by androgen blockade

Project: Research project

Project Details

Description

Triple-negative breast cancers (TNBC) account for 15-25% of breast carcinomas
and are defined by their lack of ER/PR expression, along with the absence of Her2
overexpression or gene amplification. The lack of recognized targets coupled with its aggressive
biology makes this subset of breast cancer a subject of intensive effort for new molecular target
identification. Our group developed a systematic high-throughput method for profiling
therapeutic sensitivity and applied this technology to identify genetic determinants of therapeutic
resistance (1). Our studies implicated several cellular pathways associated with radio- and
chemo-resistance.
StatusFinished
Effective start/end date2/1/2012/31/20

Funding

  • ASCO Cancer Foundation (AGMT 5/20/20)

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