Targeting the Oncometabolism with Mitochondria-Directed Chemicals

Project: Research project

Project Details


This project proposes that the disruption of the mutual regulatory mechanisms between OXPHOS and glycolysis promotes the metabolic uncoupling which is critical for tumor progression. It is also proposed that the use of mitochondria-targeted chemicals can eliminate cells with metabolic uncoupling and a specific molecular signature predictive of aggressive breast cancer.
Effective start/end date3/1/205/16/21


  • Medical College of Wisconsin (AGMT Bonini 7/7/21 // W911NF1910287)
  • Army Research Office (AGMT Bonini 7/7/21 // W911NF1910287)


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