The 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repair

In this U01 proposal with Dr. Yarui Diao from Duke University, we will process all the genomic data, including Hi-C, ChIP-Seq, and RNA-Seq experiments. We will identify differential gene expression for the normal and disease cells, predict ChIP-Seq peaks, and also perform motif analysis. For the Hi-C data, we will systematically identify chromatin loops, TADs, compartments, as well as dynamic 3D genome features.