The effect of BRCA1 haploinsufficiency on the transcriptome and phenotype of breast epithelial cells

Project: Research project

Description

The goals of the proposed research match up well with those of mission of the Lynn Sage Cancer Research Foundation in that we seek to understand the mechanisms of BRCA mediated oncogenesis and, by doing so, to develop innovative methods for its prevention. The proposed research complements that of our close collaborator, Dr. Seema Khan as outlined in her proposal entitled: "The role of progesterone receptor and glucocorticoid receptor in the promotion of tumorigenesis in BRCA mutation carriers.”
StatusFinished
Effective start/end date9/1/158/31/18

Funding

  • Northwestern Memorial Hospital (NMH09102015//ExhibitB.10)

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Haploinsufficiency
Transcriptome
Breast
Epithelial Cells
Phenotype
Carcinogenesis
Research
Glucocorticoid Receptors
Progesterone Receptors
Mutation
Neoplasms