The proposed research consists of two aims that directly relate to the immunology and immunotherapy of chordoma. The first aim will examine the immune composition of chordoma patients and the ability of their immune cells to kill tumor tissue. In the second aim, we will generate a humanized mouse model of chordoma, to provide preclinical information about the effectiveness of immunotherapy for this malignancy. The aims will provide an answer to our central hypothesis that chordomas build an immunosuppressive microenvironment to support their own growth. Below is a detailed description of each aim and how it will be executed.
|Effective start/end date||7/1/21 → 6/30/23|
- Cancer Research Institute (CRI3733)
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