The overall goal of this project is to identify systemic immune factors that contribute to the development of brain metastases in patients with lung cancer. Identification of these factors is critical as predictive biomarkers in patients at risk for metastasis and as therapeutic targets to prevent the development of metastases. While most studies to date have focused on identifying genomic changes in the tumor that promote metastasis, this project takes a novel approach, focusing on systemic immune factors influenced by the tumor to combat metastatic disease to the brain. In order to address the overall goal, we will investigate the following specific aims: Aim 1: To identify differences in peripheral immune phenotype between NSCLC patients with and without brain metastases Aim 2: To identify changes in peripheral immune phenotype in patients with NSCLC that predict the development of brain metastases Aim 3: To develop a preclinical model for studying tumor derived factors that influence peripheral immune phenotype in NSCLC
|Effective start/end date||1/1/17 → 12/31/17|
- Northwestern Memorial Hospital (NMH Agmt #10 Signed 01/01/2017)
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